Think Melatonin is Safe? New Research Reveals a Hidden Heart Risk
Long-term use of melatonin for sleep disorders may pose unexpected dangers to the heart. Recent research indicates that chronic melatonin users face nearly double the risk of death and a 3.5 times higher chance of hospitalization due to heart failure.
Link Between Long-Term Melatonin Use and Heart Failure
Individuals who regularly take melatonin to aid sleep could encounter serious cardiovascular problems. A preliminary study presented at the American Heart Association's (AHA) Scientific Sessions 2025 showed that adults suffering from chronic insomnia and using melatonin for a year or longer had an increased risk of developing heart failure, hospitalization because of heart failure, and all-cause mortality compared to non-users.
The findings will be discussed at the AHA's annual meeting held November 7–10 in New Orleans, a major event featuring the latest updates in cardiovascular science and clinical research.
About Melatonin
Melatonin is a hormone produced by the pineal gland that controls the sleep-wake cycle, naturally rising in darkness and falling in daylight. Synthetic melatonin, identical to its natural form, is commonly used to treat insomnia and jet lag.
- In the U.S. and several other countries, melatonin supplements are available over-the-counter.
- Because U.S. melatonin products are not regulated, their purity and dosage vary significantly.
Expert Recommendations
Despite melatonin’s reputation as a harmless sleep aid, experts now advise caution with prolonged use due to these newly discovered cardiac risks.
Author’s summary: New evidence links long-term melatonin use to increased heart failure risk and mortality, urging careful reconsideration of chronic use despite its general safety reputation.